Original
By certification 
DMF No.: 030168
Name: hydroxypropyl- beta-cyclodextrin
Other name : hydroxypropyl betadex ; 2-hydroxypropyl-beta-cyclodextirn ;
Hydroxypropyl-β-cyclodextrin .
Abbreviation : HPBCD
CAS: 128446-35-5; 94035-02-6; 136019-12-0
EINECS: 420-920-1
Molecular formula :C42H70-nO35(C3H8O2)n
Molecular weight: 1134.98+58n
Solubility(in 100cm3 solvent, at 25℃) : water: >180 g
Methanol: >33g
DMSO: >33g
Qaulity ： Pharma grade / food grade / cosmetics grade / industry grade
Standard : USP39/ EP8.04/ CP2015
Package: 500g/bag , 2kg/bag, 10kg/drum , 20kg/drum or customized
Use : medical \ food \ chemical \ cosmetic \ other industries
Specification :
| ITEMS | SPECIFICATION(USP39) |
RESULTS |
Appearance |
white powder, insipid, innocent |
Qualify |
Assay |
≥98％ |
99.5% |
Degree of Substitution |
2.8-10.5 |
5.5 |
Clarity of solution |
50%(w/v) water solution is clear |
clear |
Identification(IR) |
same absorption bands with USP Hydroxypropyl Betadex RS |
Qualify |
Loss on Drying |
≤10％ |
4.5% |
|
Conductivity |
10%(w/v) water solution ≤200µS/cm |
70 |
Propylene oxide |
≤1ppm |
＜0.18ppm |
Propylene glycol |
≤2.5％ |
0.05% |
Sum of Other Impurities |
≤1％ |
0.51% |
Betadex |
≤1.5% |
0.39% |
Residue on Ignition |
≤0.2％ |
0.09% |
Heavy Metal |
≤20ppm |
＜10ppm |
chloride |
≤0.05% |
＜0.05% |
Bacterial endotoxins |
≤25EU/g |
<20EU/g |
TAMC(cfu/g) |
≤1000 |
80 |
TYMC(cfu/g) |
≤100 |
30 |
Salmonella/E. Coli (cfu/g) |
Absent |
Absent |
Storage: at room temperature, in tightly closed container.
Applications:
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is one of the most widely used cyclodextrin derivatives in current scientific researches and industry applications. It mainly used in food, pharmaceutical and cosmetics industries.
